Model-Informed Drug Discovery & Development Aids in the Design & Dose Prediction for Multispecific Therapeutics

Time: 11:30 am
day: Track B Day 2 AM


  • Identify tradeoffs between target and drug properties and efficacy to identify key missing data and maximize therapeutic index in osteo-arthritis
  • Predict trimer levels and receptor occupancy for a T-cell Engager in solid tumors to support dose selection in the expansion part of a phase 1/2 trial
  • Provide a rational basis for clinical dose selection for a bispecific therapeutic targeting solid tumors