LAG3-Targeted IL15/IL15Rα-Fc (LAG3 x IL15) Fusion Protein for Preferential TIL Expansion

Time: 1:00 pm
day: Focus Day Track B - PM


  • Engineering LAG3 x IL15 bispecific Fc fusions for optimal activity to LAG3+ TIL with minimal peripheral activity
  • Demonstrating potent activity and high selectivity for LAG3+ cell populations in multiple in vitro and in vivo models
  • Showing a promising profile of selective delivery to LAG3+ cells and may preferentially expand LAG3+ TIL in patients with cancer, while potentially avoiding systemic toxicity due to off-target activation and expansion of peripheral lymphocytes