Programmable Half-Life & Anti-Tumour Effects of Bi-Specific T-Cell Engager-Albumin Fusions with Tuned FcRn Affinity

Time: 10:30 am
day: Focus Day Track B - AM


  • Exploit FcRn-driven cellular recycling of albumin as an alternative to an Fc half-life extension approach
  • Inclusion of albumin sequences with different FcRn affinity to tune cellular recycling and pharmacokinetics of bi-specific T-cell engagers
  • Evaluation in humanised albumin/FcRn murine models