8:45 am Chair’s Opening Remarks
8:50 am Uncovering the Therapeutic Potential of a Next Generation Tumor Treg Deplete
Synopsis
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Developing Next Generation Multispecifics for a Flourishing Future
9:20 am Session Reserved for Gem Pharmatech
Synopsis
9:30 am Guided Antibody Tumor Engagers (TwoGATE™), a Sophisticated & Differentiated Approach for T Cell Redirection in Solid Tumors
Synopsis
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10:00 am
Morning Break & Speed Networking
Synopsis
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Target Discovery, Mechanistic Diversity & Translational Science
Translational Science
11:00 am Translational PK/PD Investigations & Multiscale Mechanism-Based Modeling to Support Development of T Cell Redirecting Antibodies
Synopsis
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11:30 am PreTarg-it®: A modular platform utilizing bispecific antibodies for optimized biodelivery of payloads.
Synopsis
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12:00 pm Session Reserved for Asimov
Synopsis
Novel Formats, Product Design & Manufacturability
Manufacturability
11:00 am High throughput SPR characterization of multi-specific antibodies. Capabilities and workflow approaches advancing discovery
Synopsis
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11:30 am Potency Assay Strategy from Early to Late Clinical Development: A Bispecifics Case Study
Synopsis
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12:00 pm Session Reserved for Applied BioMath
Synopsis
12:30 pm
Lunch & Networking
Solid Tumor Engagers
1:30 pm Decoupling Cytotoxicity with Cytokine Release: Development of Safe CD3 T Cell Engagers for Solid Tumors
Synopsis
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2:00 pm Overcoming the Challenges of a First-Generation CD123-Directed Bispecific CD3-Engaging DART Molecule
Synopsis
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2:30 pm Generation of Innovative B7H4 x CD3 & B7H4 x 4-1BB Bispecifics for Solid Tumor Therapies
Synopsis
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Data & AI
1:30 pm Graphical Design, Engineering & In Silico Cloning of Multispecific Antibodies
Synopsis
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2:00 pm TREAT 2.0: A Versatile Platform Technology for Development of Multispecific Antibodies
Synopsis
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2:30 pm Leveraging Homotypic Antibody Interfaces for Biotherapeutic Engineering
Synopsis
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3:00 pm
Afternoon Break & Networking
Multispecifics in Clinical Use & Combinational Mechanisms
4:00 pm Improving Bispecific Antibody Outcome in Acute Myeloid Leukemia
Synopsis
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4:30 pm Panel Discussion – Unlocking the Potential of Combinatorial Strategies of Bispecifics in a Clinical Setting
Synopsis
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