8:45 am Chair’s Opening Remarks

8:50 am Uncovering the Therapeutic Potential of a Next Generation Tumor Treg Deplete

Synopsis

For more information on this session, please download the full event guide.

Developing Next Generation Multispecifics for a Flourishing Future

9:20 am Session Reserved for Gem Pharmatech

Synopsis

9:30 am Guided Antibody Tumor Engagers (TwoGATE™), a Sophisticated & Differentiated Approach for T Cell Redirection in Solid Tumors

Synopsis

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10:00 am
Morning Break & Speed Networking

Synopsis

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Target Discovery, Mechanistic Diversity & Translational Science

Translational Science

11:00 am Translational PK/PD Investigations & Multiscale Mechanism-Based Modeling to Support Development of T Cell Redirecting Antibodies

  • Aman Singh Associate Director, Cell Therapy Clinical Pharmacology, Modeling & Bioinformatics, Takeda

Synopsis

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11:30 am PreTarg-it®: A modular platform utilizing bispecific antibodies for optimized biodelivery of payloads.

Synopsis

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12:00 pm Session Reserved for Asimov

Synopsis

Novel Formats, Product Design & Manufacturability

Manufacturability

11:00 am High throughput SPR characterization of multi-specific antibodies. Capabilities and workflow approaches advancing discovery

Synopsis

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11:30 am Potency Assay Strategy from Early to Late Clinical Development: A Bispecifics Case Study

  • Azra Mujic-Delic Principal Scientist - Functional Characterization & Bioassays, Genmab

Synopsis

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12:00 pm Session Reserved for Applied BioMath

Synopsis

12:30 pm
Lunch & Networking

Solid Tumor Engagers

1:30 pm Decoupling Cytotoxicity with Cytokine Release: Development of Safe CD3 T Cell Engagers for Solid Tumors

Synopsis

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2:00 pm Overcoming the Challenges of a First-Generation CD123-Directed Bispecific CD3-Engaging DART Molecule

Synopsis

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2:30 pm Generation of Innovative B7H4 x CD3 & B7H4 x 4-1BB Bispecifics for Solid Tumor Therapies

  • Musheng Bao Senior Director, Discovery Oncology, Harbour Biomed

Synopsis

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Data & AI

1:30 pm Graphical Design, Engineering & In Silico Cloning of Multispecific Antibodies

Synopsis

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2:00 pm TREAT 2.0: A Versatile Platform Technology for Development of Multispecific Antibodies

  • Ankita Srivastava Vice President - Protein Sciences & Rational Design, Ichnos Sciences

Synopsis

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2:30 pm Leveraging Homotypic Antibody Interfaces for Biotherapeutic Engineering

  • Brandon Leonard Principal Scientific Researcher - Antibody Engineering, Genentech

Synopsis

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3:00 pm
Afternoon Break & Networking

Multispecifics in Clinical Use & Combinational Mechanisms

4:00 pm Improving Bispecific Antibody Outcome in Acute Myeloid Leukemia

Synopsis

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4:30 pm Panel Discussion – Unlocking the Potential of Combinatorial Strategies of Bispecifics in a Clinical Setting

  • Prathap Shastri Scientific Director, DMPK, Preclinical Sciences and Translational Safety, Johnson & Johnson
  • Laura von Schantz Vice President Discovery, Alligator Bioscience

Synopsis

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5:00 pm Chair’s Closing Remarks