8:25 am Chair’s Opening Remarks

8:30 am The Landscape of Bi/Multispecifics

Synopsis

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Uncovering the Multispecifics Landscape for a Holistic Overview

9:00 am Looking to Satisfy the Growing Demand of Capacity and Capabilities for Biologics

Synopsis

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9:10 am Panel Discussion – CAR T vs. Multispecifics

Synopsis

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9:45 am
Speed Networking

Synopsis

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10:15 am
Morning Break

Target Discovery, Mechanistic Diversity & Translational Science

Target Discovery

10:45 am On and Off-Target Toxicities of Bispecific Targeted Biologics: Mitigation Strategies

  • Rakesh Dixit President and Head of R&D, Co-Founder, Regio Biosciences

Synopsis

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11:15 am Early Developability of Multispecifics

  • Vera Sellers Associate Director - Molecule Group, Protein & Cell Sciences Discovery & Development Technologies, EMD Serono

Synopsis

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11:45 am Session Reserved for Discovery

  • Jonah Rainey, PhD VP of Antibody Engineering and Protein Science, AlivaMab Discovery Services

Synopsis

Novel Formats, Product Design & Manufacturability

Novel Formats

10:45 am Engineering Safe & Effective Bispecific Immunotherapies for Solid Tumor Indications

  • Shaun Lippow Vice President, Drug Discovery & Protein Engineering, Atreca

Synopsis

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11:15 am Target Biology & Antibody Attributes Drive Multispecific Format Selection & Engineering

Synopsis

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11:45 am High Specificity OmniAb Antibodies for Bispecific Applications

Synopsis

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12:15 pm
Lunch & Networking

Mechanistic Diversity

1:15 pm CLEC5a-Directed Bispecific Antibody for Effective Cellular Phagocytosis

Synopsis

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1:45 pm Kick-Starting Tumor Specific T Cell Cross-Priming Using Neo-X-Prime Bispecific Antibodies Targeting CD40

Synopsis

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2:15 pm Expanding the Therapeutic Window for Immune- Engaging Multi-Specifics Through Conditional Activation & Co-Stimulation

  • David Poon Vice President – Business Development & Alliance Management, Zymeworks

Synopsis

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2:45 pm Retrospective Look at Translational Considerations & FIH Dosing Approaches for T-cell Redirectors

  • Prathap Shastri Scientific Director, DMPK, Preclinical Sciences and Translational Safety, Johnson & Johnson

Synopsis

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Product Design

1:15 pm ISB 1442, a First-in-Class 2+1 Fc Engineered Biparatopic Bispecific BEAT® 2.0 antibody targeting CD38 and CD47

Synopsis

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1:45 pm Correlating Multispecific Structures to their Functions for a Holistic Overview of Product Design

Synopsis

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2:15 pm VIRTUAL: Exploring the Consequences of Codon Optimization on Therapeutic Sequences

  • Chava Kimchi-Sarfaty Deputy Associate Director - Research Office of Tissue & Advanced Therapies, CBER, FDA

Synopsis

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2:45 pm Rational Engineering of an Erythropoietin Fusion Protein to Treat Hypoxia”

  • Jeffrey Way Lecturer - Department of Systems Biology, Harvard Medical School

Synopsis

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3:15 pm
Afternoon Break & Networking

Extrapolating Clinical Trial Design Learnings for the Best Shot at Success

4:15 pm CB307: A Novel T Cell Costimulatory Humabody VH Therapeutic for PSMA-Positive Tumors

Synopsis

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4:45 pm Chair’s Closing Remarks

4:50 pm Scientific Poster Session

Synopsis

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